1921 Circuito di Brescia
12 September - Brescia: 20 laps x 17.3 km = 346 km

 Pole Position: N/A
 Fastest Lap: N/A 

Results:

  1 Franz Conelli        Bugatti 22                       3:10.12.0
  2 Mario Danieli        OM 465                           3:16.28.0
  3 Pietro Iliprandi     OM 465                           3:22.10.4
  4 Luigi Desio          OM 465                           3:50.00.4

Did Not Finish:

    Carlo Gambetti       Buriani                               9  Mechanical
    Filippo Ardizzone    Ansaldo 4CS                           8  Mechanical
    Giulio Sirtori       Bianchi 12                            8  Mechanical 
    Ferruccio Cercignani Wanderer 5/15PS                       6  Valves
    Tazio Nuvolari       Ansaldo 4CS                           1  Oil pump 
 
Race Note:
 1) Last (fourth) race of the "Settimana di Brescia" (Brescia Week).